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1

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Schreiber, Stuart L., Kotz, Joanne D., Li, Min, Aubé, Jeffrey, Austin, Christopher P., Reed, John C., Rosen, Hugh, White, E. Lucile, Sklar, Larry A., Lindsley, Craig W., Alexander, Benjamin R., Bittke

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2015

2

ChemInform Abstract: Regiocontrol in an Intramolecular Schmidt Reaction: Total Synthesis of (+)-Aspidospermidine.

Rajesh Iyengar, Klaas Schildknegt, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 31 KB

2000

3

Intramolecular Schmidt reactions of alkyl azides with ketals and enol ethers

Craig J. Mossman, Jeffrey Aubé

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 342 KB

english, 1996

4

Intramolecular Schmidt reaction of alkyl azides

Aube, Jeffrey, Milligan, Gregory L.

Journal:

Journal of the American Chemical Society

Année:

1991

Langue:

english

Fichier:

PDF, 283 KB

english, 1991

5

Intramolecular Schmidt Reactions of Alkyl Azides with Ketones: Scope and Stereochemical Studies

Milligan, Gregory L., Mossman, Craig J., Aube, Jeffrey

Journal:

Journal of the American Chemical Society

Année:

1995

Langue:

english

Fichier:

PDF, 1.45 MB

english, 1995

6

Drug Repurposing and the Medicinal Chemist

Journal:

ACS Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 151 KB

english, 2012

7

Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction

Motiwala, Hashim F., Fehl, Charlie, Li, Sze-Wan, Hirt, Erin, Porubsky, Patrick, Aubé, Jeffrey

Journal:

Journal of the American Chemical Society

Année:

2013

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2013

8

Probing chemical space with alkaloid-inspired libraries

McLeod, Michael C., Singh, Gurpreet, Plampin, James N., Rane, Digamber, Wang, Jenna L., Day, Victor W., Aubé, Jeffrey

Journal:

Nature Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.87 MB

english, 2014

9

Solution-Phase Parallel Synthesis of a Library of Δ 2 -Pyrazolines

Manyem, Shankar, Sibi, Mukund P., Lushington, Gerald H., Neuenswander, Benjamin, Schoenen, Frank, Aubé, Jeffrey

Journal:

Journal of Combinatorial Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 215 KB

english, 2007

10

Synthesis and rearrangement of a bridged thioamide

Szostak, Michal, Aubé, Jeffrey

Journal:

Chemical Communications

Année:

2009

Langue:

english

Fichier:

PDF, 516 KB

english, 2009

11

Hexafluoro-2-propanol-Promoted Intermolecular Friedel–Crafts Acylation Reaction

Vekariya, Rakesh H., Aubé, Jeffrey

Journal:

Organic Letters

Année:

2016

Langue:

english

Fichier:

PDF, 726 KB

english, 2016

12

ChemInform Abstract: Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction.

Vekariya, Rakesh H., Aube, Jeffrey

Journal:

Année:

2016

Fichier:

PDF, 23 KB

2016

13

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A

Cooper, Jason K., Li, Kelin, Aubé, Jeffrey, Coppage, David A., Konopelski, Joseph P.

Journal:

Organic Letters

Année:

2018

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2018

14

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

Chun, Lani S., Vekariya, Rakesh H., Free, R. Benjamin, Li, Yun, Lin, Da-Ting, Su, Ping, Liu, Fang, Namkung, Yoon, Laporte, Stephane A., Moritz, Amy E., Aubé, Jeffrey, Frankowski, Kevin J., Sibley, Dav

Journal:

Frontiers in Synaptic Neuroscience

Année:

2018

Langue:

english

Fichier:

PDF, 2.18 MB

english, 2018

15

The Ex Vivo Treatment of Donor T cells with Cosalane, an HIV Therapeutic and Small Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplant Models

Fowler, Kenneth A., Li, Kelin, Whitehurst, Christopher B., Bruce, Danny W., Moorman, Nathaniel J., Aubé, Jeffrey, Coghill, James M.

Journal:

Biology of Blood and Marrow Transplantation

Année:

2019

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2019

16

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates

McLaughlin, Jacqueline E., Minshew, Lana M., Gonzalez, Daniel, Lamb, Kelsey, Klus, Nicholas J., Aubé, Jeffrey, Cox, Wendy, Brouwer, Kim L. R., Hermes-Lima, Marcelo

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 381 KB

english, 2019

17

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates

McLaughlin, Jacqueline E., Minshew, Lana M., Gonzalez, Daniel, Lamb, Kelsey, Klus, Nicholas J., Aubé, Jeffrey, Cox, Wendy, Brouwer, Kim L. R., Hermes-Lima, Marcelo

Journal:

Année:

2019

Fichier:

PDF, 381 KB

2019

18

A Combined Intramolecular Diels–Alder/Intramolecular Schmidt Reaction: Formal Synthesis of (±)-Stenine

Jennifer E. Golden, Jeffrey Aubé

Journal:

Angewandte Chemie

Année:

2002

Langue:

english

Fichier:

PDF, 76 KB

english, 2002

19

A Combined Intramolecular Diels–Alder/Intramolecular Schmidt Reaction: Formal Synthesis of (±)-Stenine

Jennifer E. Golden, Jeffrey Aubé

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 76 KB

english, 2002

20

Highly Stereoselective Ring Expansion Reactions Mediated by Attractive Cation–n Interactions

Timothy Ribelin, Christopher E. Katz, Donna G. English, Sherriel Smith, Anna K. Manukyan, Victor W. Day, Benjamin Neuenswander, Jennifer L. Poutsma, Jeffrey Aubé

Journal:

Angewandte Chemie

Année:

2008

Langue:

english

Fichier:

PDF, 292 KB

english, 2008

21

1,3-Allylic Strain as a Strategic Diversification Element for Constructing Libraries of Substituted 2-Arylpiperidines

Dr. Thomas C. Coombs, Dr. Gerald H. Lushington, Dr. Justin Douglas, Prof. Dr. Jeffrey Aubé

Journal:

Angewandte Chemie

Année:

2011

Langue:

english

Fichier:

PDF, 583 KB

english, 2011

22

Highly Stereoselective Ring Expansion Reactions Mediated by Attractive Cation–n Interactions

Timothy Ribelin, Christopher E. Katz, Donna G. English, Sherriel Smith, Anna K. Manukyan, Victor W. Day, Benjamin Neuenswander, Jennifer L. Poutsma, Jeffrey Aubé

Journal:

Angewandte Chemie International Edition

Année:

2008

Langue:

english

Fichier:

PDF, 292 KB

english, 2008

23

1,3-Allylic Strain as a Strategic Diversification Element for Constructing Libraries of Substituted 2-Arylpiperidines

Dr. Thomas C. Coombs, Dr. Gerald H. Lushington, Dr. Justin Douglas, Prof. Dr. Jeffrey Aubé

Journal:

Angewandte Chemie International Edition

Année:

2011

Langue:

english

Fichier:

PDF, 572 KB

english, 2011

24

In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format

Dr. Thomas O. Painter, Dr. Paul D. Thornton, Mario Orestano, Dr. Conrad Santini, Prof. Michael G. Organ, Prof. Jeffrey Aubé

Journal:

Chemistry - A European Journal

Année:

2011

Langue:

english

Fichier:

PDF, 395 KB

english, 2011

25

ChemInform Abstract: Synthetic Routes to Lactam Peptidomimetics

Journal:

Année:

1999

Fichier:

PDF, 23 KB

1999

26

ChemInform Abstract: Hydrolysis of Iminium Ethers Derived from the Reaction of Ketones with Hydroxy Azides: Synthesis of Macrocyclic Lactams and Lactones.

Jennifer E. Forsee, Jeffrey Aube

Journal:

Année:

1999

Fichier:

PDF, 36 KB

1999

27

ChemInform Abstract: 1,7-Asymmetric Induction in a Nitrogen Ring Expansion Process Facilitated by in situ Tethering.

Kelly Furness, Jeffrey Aube

Journal:

Année:

1999

Fichier:

PDF, 29 KB

1999

28

ChemInform Abstract: The Family Approach to the Resolution of Racemates

Kiran Sahasrabudhe, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 23 KB

2000

29

ChemInform Abstract: Cyclizations of Substituted Benzylidene-3-alkenylamines: Synthesis of the Tricyclic Core of the Martinellines.

Kristine E. Frank, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 37 KB

2000

30

ChemInform Abstract: Oxaziridines as N- and O-Functionalization Reagents

Rajesh Iyengar, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 23 KB

2000

31

ChemInform Abstract: Synthesis of α-Amino-α′-diazomethyl Ketones via Ring Opening of Substituted Cyclopropanones with Alkyl Azides. A Facile Route to N-Substituted 3-Azetidinones.

Pankaj Desai, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 32 KB

2000

32

ChemInform Abstract: Synthesis and Conformation of Gly—Gly Dipeptides Constrained with Phenylalanine-Like Aminocaproic Acid Linkers.

Mary MacDonald, David Vander Velde, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 32 KB

2000

33

ChemInform Abstract: Regiochemical Studies of the Ring Expansion Reactions of Hydroxy Azides with Cyclic Ketones.

Brenton T. Smith, Vijaya Gracias, Jeffrey Aube

Journal:

Année:

2000

Fichier:

PDF, 33 KB

2000

34

ChemInform Abstract: Reactions of Alkyl Azides and Ketones as Mediated by Lewis Acids: Schmidt and Mannich Reactions Using Azide Precursors.

Pankaj Desai, Klaas Schildknegt, Konstantinos A. Agrios, Craig Mossman, Gregory L. Milligan, Aube Jeffrey Aube Jeffrey

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 41 KB

english, 2000

35

ChemInform Abstract: Intramolecular Reactions of Benzylic Azides with Ketones: Competition Between Schmidt and Mannich Pathways.

Aaron Wrobleski, Jeffrey Aube

Journal:

Année:

2001

Fichier:

PDF, 31 KB

2001

36

ChemInform Abstract: Approaches to Cyclic Peptide β-Turn Mimics

Mary MacDonald, Jeffrey Aube

Journal:

Année:

2001

Fichier:

PDF, 26 KB

2001

37

Asymmetric Total Synthesis of Dendrobatid Alkaloid 251F.

Aaron Wrobleski, Kiran Sahasrabudhe, Jeffrey Aube

Journal:

Année:

2003

Fichier:

PDF, 60 KB

2003

38

Total Syntheses of Martinella Alkaloids

Weston R. Judd, Jeffrey Aube

Journal:

Année:

2003

Fichier:

PDF, 48 KB

2003

39

Asymmetric Schmidt Reaction of Hydroxyalkyl Azides with Ketones.

Kiran Sahasrabudhe, Vijaya Gracias, Kelly Furness, Brenton T. Smith, Christopher E. Katz, D. Srinivasa Reddy, Jeffrey Aube

Journal:

Année:

2003

Fichier:

PDF, 203 KB

2003

40

Lewis Acid Mediated Reactions of Alkyl Azides with α,β-Unsaturated Ketones.

D. Srinivasa Reddy, Weston R. Judd, Jeffrey Aube

Journal:

Année:

2004

Fichier:

PDF, 189 KB

2004

41

Rearrangements of Bicyclic Nitrones to Lactams: Comparison of Photochemical and Modified Barton Conditions.

Yibin Zeng, Brenton T. Smith, John Hershberger, Jeffrey Aube

Journal:

Année:

2004

Fichier:

PDF, 191 KB

2004

42

Unusual Tethering Effects in the Schmidt Reaction of Hydroxyalkyl Azides with Ketones: Cation—π and Steric Stabilization of a Pseudoaxial Phenyl Group.

Christopher E. Katz, Jeffrey Aube

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 124 KB

english, 2004

43

Ring Expansive Routes to Quinolizidine Alkaloids: Formal Synthesis of (-)-Lasubine II.

Vijaya Gracias, Yibin Zeng, Pankaj Desai, Jeffrey Aube

Journal:

Année:

2004

Fichier:

PDF, 60 KB

2004

44

Base-Promoted Reactions of Bridged Ketones and 1,3- and 1,4-Haloalkyl Azides: Competitive Alkylation vs Azidation Reactions of Ketone Enolates.

Lei Yao, Brenton T. Smith, Jeffrey Aube

Journal:

Année:

2004

Fichier:

PDF, 110 KB

2004

45

Domino Reactions that Combine an Azido-Schmidt Ring Expansion with the Diels—Alder Reaction.

Yibin Zeng, D. Srinivasa D. Reddy, Erin Hirt, Jeffrey Aube

Journal:

Année:

2005

Fichier:

PDF, 46 KB

2005

46

Modular Synthesis of Cyclic Peptidomimetics Inspired by γ-Turns.

Senthil Kumar Ramanathan, John Keeler, Huey-Lih Lee, D. Srinavasa Reddy, Gerald Lushington, Jeffrey Aube

Journal:

Année:

2005

Fichier:

PDF, 24 KB

2005

47

Regioselective Single and Double Conjugate Additions to Substituted Cyclohexa-2,5-dienone Monoacetals.

Scott Grecian, Aaron D. Wrobleski, Jeffrey Aube

Journal:

Année:

2005

Fichier:

PDF, 36 KB

2005

48

ChemInform Abstract: Synthesis and Rearrangement of a Bridged Thioamide.

Michal Szostak, Jeffrey Aube

Journal:

Année:

2010

Fichier:

PDF, 22 KB

2010

49

ChemInform Abstract: Synthesis, Structural Analysis, and Reactivity of Bridged Orthoamides by Intramolecular Schmidt Reaction.

Michal Szostak, Jeffrey Aube

Journal:

Année:

2010

Fichier:

PDF, 50 KB

2010

50

ChemInform Abstract: A Tandem Prins/Schmidt Reaction Approach to Marine Alkaloids: Formal and Total Syntheses of Lepadiformines A (XVI) and C (XVII).

Angelica M. Meyer, Christopher E. Katz, Sze-Wan Li, David Vander Velde, Jeffrey Aube

Journal:

Année:

2010

Fichier:

PDF, 31 KB

2010